Correlation of CDX2 Protein Expression with Clinicopathologic Features and Survival Rate in Iraqi Patients with Colorectal Cancer
نویسندگان
چکیده
Predicting the prognosis of colorectal cancer (CRC) is challenging since these tumors exhibit a wide range biological behaviors. It has been hypothesized that caudal-related homeobox gene 2 (CDX2), which vital for intestinal growth and maintenance, tumor-suppressing effect promising role in CRC but studies are still controversial. This study used immunohistochemical (IHC) staining method to determine expression CDX2 protein mucinous non-mucinous adenocarcinoma, as well normal tissues control, correlate this with clinicopathological features such grade, tumor distant metastasis, site, histological type, lymph node invasion, sex, age, rate 4 years Overall survival (OS) after diagnosis. A total sixty three tissue samples were obtained from patients (58.90±14.94) embedded wax thirty-seven non-tumoural (56.43±12.28) control group. decreased significantly (p<0.05) than advanced pattern CRC, moderate poorly differentiated grades, invasion (T3, T4), organs metastasis. Moreover, low was (17.943±1.7) months compared (33.431±2.7) those high (p = 0.0001). concluded regarded prognostic diagnostic marker patients.
منابع مشابه
correlation of colorectal cancer stem cell marker cd24 expression with clinicopathologic features and survival of patients with colorectal cancer
background : cancer stem cells are a subgroup of tumor cells that have the capability for self-renewal and differentiation and are characterized by multiple markers. several studies have been conducted to identify these cells in colorectal cancer, including stem cell marker cd24. this study has evaluatedtheassociation of cd24 expression with clinicopathologic features and survival in an immunoh...
متن کاملevaluation of vegf immunohistochemical expression and correlation with clinicopathologic features in colorectal cancer
background: vascular endothelial growth factor (vegf) is a signal protein produced by cells that stimulates angiogenesis and increased vascular permeability. the prognostic value of vegf expression in colorectal cancer is unclear as shown by the discordant results still reported in the literature. this study was designed for the evaluation of vegf expression and correlation with clinicopatholog...
متن کاملThe association between CD166 detection rate and clinicopathologic parameters of Patients with colorectal cancer
Background: Metastasis and recurrence of colorectal cancer after treatment is attributed to stem cells. The aim of this study was to determine the relationship between the expression of stem cell marker CD166 in colorectal cancer by immunohistochemistry and clinicopathologic parameters.Methods: From 2006 to 2012, 121 colectomy specimens of patients with colon cancer that were operated in Babol...
متن کاملAssociation of CD166 expression with clinicopathologic characteristics of colorectal cancer
متن کامل
Clinical and Pathological Features of Iraqi Patients with Prostate Cancer
Background: The clinical pathological features were detected by measuring the prostatic acid phosphatase (PAP) activity according to the stages and grades of prostate cancer. We also explored the relationship between the disease and age with family history among the patients. Methods: Data were collected from direct interview and from the patient’s records. Blood samples that collected before ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hayati Journal of Biosciences
سال: 2023
ISSN: ['1978-3019', '2086-4094']
DOI: https://doi.org/10.4308/hjb.30.3.551-560